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Collectively, this work describes a mechanistic framework of riboflavin dependency in AML and defines a previously unappreciated interplay between riboflavin, pyrimidine biosynthesis and Fe-S metabolism

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The efforts of all who helped in the preparation and finalization of this monograph are gratefully acknowledged

CD38 is also involved in gliomas where it supports the activation of tumor microglia and macrophages and subsequent tumor progression [55]